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KMID : 0894520090130020089
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Development & Reproduction
2009 Volume.13 No. 2 p.89 ~ p.95
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Expression of p63 during Early Craniofacial Development of the Mouse Embryo
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Hosoya Akihiro
Lee Jong-Min
Kim Ji-Youn
Jung Han-Sung
Cho Sung-Won
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Abstract
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p63 has been demonstrated to localize in stem cells and precursor cells of various epithelial tissues previously, but the localization of p63 throughout tooth formation, particularly during the enamel and root formation stages, remains to be adequately characterized. Therefore, in this study, we have demonstrated, via immunohistochemical methods, that p63 is ubiquitously expressed in the dental epithelium during tooth development. p63 was detected in the basal and suprabasal layers of the epithelia, including the skin, hair follicles, oral mucosa, and submandibular ducts. However, in the tooth region, all cells of the dental lamina, enamel organ, Hertwig’s epithelial root sheath (HERS), and epithelial cell rests of Malassez (ERM
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KEYWORD
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p63, Tooth development, Dental epithelium, Hertwig’s epithelial root sheath, Epithelial cell rests of Malassez
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